The present invention relates to an entrance disinfecting device. More specifically, the present invention relates to an entrance disinfecting device installed in an entrance of a livestock farm, a general building, or the like to disinfect pathogenic microorganisms when an external passenger passes therethrough, thereby controlling several sorts of infectious diseases. To this end, the entrance disinfecting device of the present invention comprises: a housing unit (100) including a vertical housing (110) having a concave groove part (116) formed in the top thereof, and a horizontal housing (120) having a projection part (122) formed toward the bottom thereof to be fitted to and coupled with the concave groove part (116) and coupled by a coupling means to have a height adjusted, wherein the vertical housing (110) and the horizontal housing (120) are disposed in parallel with respect to each other; a spraying unit (200) including multiple spraying nozzles (240) disposed in the vertical housing (110) and the horizontal housing (120) and installed toward a direction where an external passenger passes, and an air compressor (230) for pumping a medicinal fluid accommodated in a medicinal fluid container (220) by a medicinal fluid transferring pipe (210) as a medium and spraying the medicinal fluid at high pressure through the spraying nozzles (240); two or more proximal sensors (300) installed to be separated at particular intervals in longitudinal direction in the entrance side of the housing unit (100); a UV sterilizing lamp (400) installed in one side on the bottom surface of the horizontal housing (120) to emit light toward a direction where an external passenger passes; and a control unit (500) for controlling operations of the spraying unit (200) and the UV sterilizing lamp (400) on the basis of a signal sensed by the proximal sensors (300).본 발명은 출입구 방역장치에 관한 것으로, 보다 상세하게는 축산 농가 및 일반건물 등의 출입구에 설치하여 외래출입자가 통과함에 따라 병원성 미생물을 방역함으로써 각종 전염병을 방제(防除)할 수 있는 출입구 방역장치에 관한 것이