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UN NUOVO ANTICORPO ANTI-ERBB2
专利权人:
ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI SPA
发明人:
SIBILIO, LEONARDO,SIBILIO LEONARDO,GIACOMINI, PATRIZIO,GIACOMINI PATRIZIO
申请号:
ITUA20162242
公开号:
ITUA20162242A1
申请日:
2016.04.01
申请国别(地区):
IT
年份:
2017
代理人:
摘要:
The present invention relates to an antibody, particularly a monoclonal antibody, which binds a novel epitope of the ERBB2 tyrosine kinase receptor, wherein the unique features of said binding enable interference with receptor-mediated signalling and downstream biological effects in a novel and unanticipated fashion not obtainable with state-of-the-art therapeutic antibodies. The present invention relates to compositions comprising such an antibody and its humanized derivative, as well as methods using such an antibody and derivative, particularly in ERBB2-low/non-amplified breast cancers, particularly in combination with Trastuzumab and Pertuzumab.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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