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Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl tranferase inhibitor
专利权人:
Anne Roulston;Pierre Beauparlant
发明人:
Anne Roulston,Pierre Beauparlant
申请号:
US12237755
公开号:
US08211912B2
申请日:
2008.09.25
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to methods for decreasing cellular DNA repair in a target patient; decreasing cellular NAD+ biosynthesis in a target patient; increasing efficiency of radiation therapy in a target patient; modulating nicotinamide phosphoribosyl transferase activity in a patient; or sensitizing a patient to a DNA damaging therapy. The invention relates to methods for treating a patient who received a toxic dose of an nicotinamide phosphoribosyl transferase inhibitor. The invention also relates to pharmaceutical compositions comprising a physiologically acceptable carrier; an effective amount of a NMPRT inhibitor; and nicotinic acid. The invention also relates to methods for treating a patient diagnosed with or suspected to have a cancer deficient in nicotinic acid pathway.
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