Patrick Lecine,Yves Levy,Gerard Zurawski,Jacques F. Banchereau
申请号：
US13424582
公开号：
US20120244155A1
申请日:
2012.03.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compositions and methods comprising high affinity monoclonal antibody conjugates against several DC receptors are described herein. The inventors prepared fusion proteins with antigens for DC-targeting vaccine generation by conjugating several M. tuberculosis protein antigens with high affinity monoclonal antibodies against several DC receptors with a view to developing novel human vaccines based on in vivo DC-targeting. The findings of studies described herein indicate that vaccines bearing TB antigens can recall a potent memory antigen-specific T cell response in vitro resulting in IFNγ secretion.
