An antibody binding to TWEAK, characterized by binding to TWEAK characterized by comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24 is useful for the treatment of cancer or autoimmune diseases, rheumatoid arthritis, psoratic arthritis, muscle diseases, e.g. muscular dystrophy, multiple sclerosis, chronic kidney diseases, bone diseases, e.g. bone degeneration in multiple myeloma, systemic lupus erythematosus, lupus nephritis, and vascular injury.本發明係關於一種與TWEAK結合之抗體，其特徵為與TWEAK結合，其特徵為包含選自由SEQ ID NO:8、SEQ ID NO:16或SEQ ID NO:24組成之群的CDR3H作為重鏈可變域，其適用於治療癌症或自體免疫疾病、類風濕性關節炎、乾癬性關節炎、肌肉疾病(例如肌肉萎縮症)、多發性硬化、慢性腎病、骨骼疾病(例如多發性骨髓瘤中之骨骼變性)、全身性紅斑狼瘡症、狼瘡腎炎及血管損傷。
