治療黑色素瘤的藥物組合农业专利-农业学术服务平台

发明人:: AGARWAL, VEENA,阿葛瓦尔　维纳,阿葛瓦爾　維納,PERIYASAMY, GIRIDHARAN,派瑞亚沙米　葛瑞得哈伦,派瑞亞沙米　葛瑞得哈倫,RATHOS, MAGGIE JOYCE,拉瑟斯　玛基乔伊斯,拉瑟斯　瑪基喬伊斯,SRIVASTAVA, ANKITA,斯里瓦斯塔瓦　安基塔,斯里瓦斯塔瓦　安基塔,SRINIVASA, SREESHA,锡里尼娃撒　苏里萨,錫里尼娃撒　蘇里薩

摘要：: The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (CDK) inhibitor represented by a compound of formula I (as described herein) or a pharmaceutically acceptable salt thereof； and at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a CDK inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a BRAF inhibitor or a MEK inhibitor.本發明有關於一種用於治療黑色素瘤的醫藥組合，該醫藥組合包括週期蛋白依賴型激酶(CDK)抑制劑以及至少一抗癌劑，該CDK抑制劑以(如本文所述的)式I化合物或其藥學上可接受鹽類表示，該至少一抗癌劑選自BRAF抑制劑或MEK抑制劑。本發明也關於一種用於治療黑色素瘤的方法，包括將治療有效量的CDK抑制劑及治療有效量的至少一抗癌劑投予需要之個體，該至少一抗癌劑選自BRAF抑制劑或MEK抑制劑。