UNIAO BRASILEIRA DE EDUCACAO E ASSISTENCIA ;UNIAO BRASILEIRA DE EDUCACAO E ASSISTENCIA , MANTENEDORA DA PUCRS; MANTENEDORA DA PUCRS
发明人:
BONORINO, CRISTINA BEATRIZ CAZABUENA,BONORINO, Cristina Beatriz Cazabuena,BORGES, THIAGO DE JESUS,BORGES, Thiago de Jesus
申请号：
BRBR2014/000258
公开号：
WO2015/113126A1
申请日:
2014.07.30
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention provides a composition for modulating MARCH-I, MHC II and/or CD86 in the cells of an ex vivo organ, that is to say an organ taken from a donor for subsequent transplantation in a recipient. In one embodiment, the composition comprises one or more organ preservation solutions in combination with an Hsp. In another embodiment, the composition of the invention comprises Hsp70 and/or one or more synthetic Hsp70-derived peptides. The composition of the invention provides preservation while at the same time reducing rejection of an organ, thus offering many advantages and solving various relevant technical problems: not only preserving the useful life of the organ but also initiating a process in the organ which inhibits acute rejection； lengthening the useful life of the organ in vivo； having local immunomodulating effects in the recipient； having an indirect impact on the quality of life of the transplant recipient by necessitating fewer immunossuppressive medications； inducing the activity of regulatory T cells (which are acknowledged to be immunosuppressors), reducing the expression of MHC molecules in the graft, reducing alloreactive expression in the recipient's lymph nodes, and lengthening the survival of the graft in the recipient.La présente invention concerne une composition pour moduler MARCH-I, MHC II et/ou CD86 dans les cellules d'un organe ex vivo, c'est-à-dire extrait du donneur en vue d'une transplantation subséquente à un receveur. Dans un mode de réalisation, ladite composition comprend une ou plusieurs solutions de conservation d'organes en combinaison avec une Hsp. Dans un autre mode de réalisation, la composition de l'invention comprend la Hsp70 et/ou un ou plusieurs peptides synthétiques dérivés de la Hsp70. La composition de l'invention permet d'assurer la conservation et, dans le même temps, de réduire le risque de rejet de l'organe, offrant ainsi de nombreux avantages et résolvant divers problèmes techniques pertinents. En ef
