Graham Beaton,Mi Chen,Timothy Richard Coon,Todd Ewing,Wanlong Jiang,Richard Lowe,Willy Moree,Nicole Smith,Warren Wade,Liren Zhao,Yun-Fei Zhu,Martin Rowbottom,Neil Ashweek
申请号：
US13293943
公开号：
US20120122891A1
申请日:
2011.11.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
