Jonathan James Hollick,Stuart Donald Jones,Claire June Flynn,Michael George Thomas
申请号：
US13910349
公开号：
US09133199B2
申请日:
2013.06.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a compound of formula (VII)I, or pharmaceutically acceptable salt or ester thereof, wherein: X is NR7； Y is O or N—(CH2)nR19； n is 1, 2 or 3； m is 1 or 2； R1 and R2 are each independently H, alkyl or cycloalkyl； R4 and R4′ are each independently H or alkyl； or R4 and R4′ together form a spiro cycloalkyl group； R19 is H, alkyl, aryl or a cycloalkyl group； R6 is OR8 or halogen； and R7 and R8 are each independently H or alkyl. Further aspects relate to pharmaceutical compositions comprising said compounds and use therefore in the treatment of proliferative disorders and the like.
