Elizabeth King,Marcelo Leonardo Bravo Cordero,Ann Taylor-Hutchinson
申请号：
GB201618204
公开号：
GB2555442A
申请日:
2016.10.27
申请国别(地区):
GB
年份:
2018
代理人:
摘要：
A composition comprising: (i) one or more layered double hydroxide (LDH)-active anion materials comprising an LDH matrix intercalated with one or more active anions, and (ii) a modifier system comprising (a) one or more surfactants, in combination with (b) one or more compounds having the generic formula MA, where M is a metal and A is an anion, is provided. Preferably the one or more surfactants are selected from sodium lauryl sulfate, lecithin and poloxamer. The modifier system preferably has a weight ratio of LDH matrix : the one or more compounds comprising the generic formula MA : the one or more surfactants of 2 : 0.1 to 4 : 0.1 to 4. Preferably the composition comprises 400mg LDH-ibuprofen (containing 200mg LDH), at least 100mg sodium carbonate and 200mg of one or more surfactants selected from sodium lauryl sulfate, poloxamer and lecithin. A formulation comprising the composition outlined is also provided wherein preferably the formulation is selected frm dry granules, tablets, caplets, orally disintegrating tablets, orally disintegrating granules, lozenges, films, capsules, powders, effervescent formulations and buccal and sub-lingual formats.
