Eugene A. Mash, Jr.,Pawel R. Kiela,Fayez K. Ghishan
申请号：
US14271251
公开号：
US09415110B1
申请日:
2014.05.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A composition and method for targeted delivery of substances to the lower GI tract comprises a base or scaffold carrier to which a drug or prodrug is fixed or covalently attached. Compound, when taken orally travels through the GI tract of a patient to the lower GI where bacterial azo reductace enzymes cleave the bonds, releasing the drug or prodrug from the base or scaffold carrier permitting the delivery of the drug to the vicinity of a target cell type in the GI tract. The base or scaffold, which remains as a by-product passes out of the GI tract in the feces.
