Methods and combination therapies useful for increasing cell mediated anti-tumor response are described. The method comprises administering to the subject a therapeutically effective amount of an immune response modifying compound and a therapeutically effective amount of one or more immunity checkpoint inhibiting compounds.(FIG.細胞媒介性抗腫瘍応答を増加させるのに有用な方法及び組合せ治療薬が記載される。本方法は、治療有効量の免疫応答修飾化合物と治療有効量の1つ以上の免疫チェックポイント阻害化合物とを対象に投与するステップを含む。【選択図】図1