Methods for treatment of cancer are provided. The methods are based on the use of both NIR photosensitizer(s) and chemotherapy agent(s). The NIR photosensitizers have a tetrapyrrolic core or reduced tetrapyrrolic core. Also provided are pharmaceutical compositions comprising NIR photosensitizer(s) and chemotherapy agent(s). Also provided are kits comprising NIR photosensitizer(s) and chemotherapy agent(s) and instructions for their use.