Daniel Joseph Dairaghi;Penglie Zhang;J. J. Kim Wright;Subhabrata Sen;Brian E. McMaster;Andrew M. K. Pennell;Wei Chen;James B. Aggen
发明人:
Andrew M. K. Pennell,James B. Aggen,J. J. Kim Wright,Subhabrata Sen,Brian E. McMaster,Daniel Joseph Dairaghi,Wei Chen,Penglie Zhang
申请号：
US12555650
公开号：
US08324216B2
申请日:
2009.09.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
