Methods and compounds for restoring mutant p53 function

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专利权人:

Inc.;PMV Pharmaceuticals

发明人:

Vu, Binh,Dominique, Romyr,Li, Hongju

申请号：

AU2017221472

公开号：

AU2017221472A1

申请日:

2017.02.17

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/