Substituted bicyclic heteroaryls of the following formulae and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegrens syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.Linvention concerne les hétéroaryles bicycliques substitués des formules suivantes, et des compositions les contenant, pour le traitement de linflammation générale, de larthrite, de maladies rhumatismales, de larthrose, de troubles intestinaux inflammatoires, de troubles oculaires inflammatoires, de troubles inflammatoires de la vessie ou de troubles de linstabilité de la vessie, du psoriasis, de problèmes cutanés avec des composants inflammatoires, détats inflammatoires chroniques comprenant, mais sans sy limiter, des maladies auto-immunes, telles que le lupus érythémateux disséminé (SLE), la myasthénie grave, la polyarthrite rhumatoïde, lencéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjoegren et lanémie hémolytiqu
