The present invention relates to the methods for using the conditionity replication defect type CMV of genetic modification to induce the immune response for cytomegalovirus (CMV). The superinfection of the different strains of primary cmv infection, the infection as caused by the reactivation of latent CMV and the CMV encountered in the past can be treated with what and/or be prevented to method of the invention. The present invention also relates to a kind of replication defect type CMV, have been changed by recombination to allow the external of virus replication to control. The present invention also includes the composition comprising the replication defect type CMV.本發明涉及使用遺傳修飾的條件性複製缺陷型CMV誘導針對巨細胞病毒(CMV)的免疫應答的方法。本發明的方法可以用於治療和/或預防原發性CMV感染、由潛伏CMV的再活化引起的感染、和以前已經遇到的CMV的不同毒株的重疊感染。本發明也涉及一種複製缺陷型CMV，其已經被重組改變以允許病毒複製的外部控制。本發明也包括包含所述複製缺陷型CMV的組合物。
