Jun-sung PARK,Dongchul SHIN,Keun-Ho RYU,Ho Chul SHIN,Sang-wook HWANG,Gwan-young KIM,Hun-Taek KIM
申请号：
US15305949
公开号：
US20170049782A1
申请日:
2015.04.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a composition comprising 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl]-2-thiophene carboxyamide as an active ingredient, manufactured by a melt extrusion method. The composition according to the present invention has a wide variety of advantages such as securing dissolution rate and bioavailability of the active ingredient, improving absorption deviation depending on whether a patient has a meal or not, and securing stability during the manufacturing process. The present invention further provides a method which can manufacture the said composition.
