STADTMUELLER, Heinz,BETZEMEIER, Bodo,SAPOUNTZIS, Ioannis
申请号：
ES09756511
公开号：
ES2690341T3
申请日:
2009.11.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Are suitable for the treatment of diseases characterized by excessive or abnormal Cell Proliferation, as well as its use for the manufacture of a Medicament with the properties mentioned above.Claim 1, characterized in that: compounds have the General formula (1) where a radical means, eventually replaced with one or several R1 EQUAL or different, selected from the group consisting of aryl and heteroaryl C6 - 15 5 - 12 members, X is o, s or CH2 r1 is H or a Radical selected from the group consisting of RaRb and replaced with one or several ra RB RC and \/ or same or different R2 is a radical selected from the group consisting of Ra and replaced with one or multiple ra RB RC and \/ or same or different, and each ra is selected independently of the rest of the Group, alkyl of C1 - 6, moped Oalquilo C3 - 10 - 16, cicloalquilalquilo C4, C6 C7 arylalkyl aryl - 10 - 16Heteroalquilo 2 - 6 members, 8 members heterocicloalquilo 3 -, 4 - heterocicloalquilalquilo heteroaryl 14 members, 12 members and heteroarilalquilo 6 - 18 members each RB is a radical and selected appropriate in each case independently of the Group comprising =, or - ORC, haloalcoxi c1-3 ocf3 Oxy -, -, - = = S, SRC, NRC, NORC nnrcrc =, =, = NN (RG) C (o) - nrcrc - onrcrc nrcrc,,,RC (ORC) - n, N - (RG) nrcrc, halogen, - CF3, - CN, - CN, - NCO -, SCN -, NO2 -, = N2, N3 -, - S - s RC (OR), (OR), ORC - S (o) 2RC, 2orc - S (o), (OR) nrcrc - S, - S (o) 2nrcrc (or RC), - I, - i 2RC (OR), (OR) 2orc, - You - You - You nrcrc (OR), (OR) 2nrcrc, - C (o) - RC. ORC, - C (o) C (o) SRC, - C (o) nrcrc, - C (o) n (RG) nrcrc, - C (o) n (RG), ORC (NRG) nrcrc - C - C (n, RC - C (OH), nrcrc Noh), OC (OC), RC (o) - ORC, OC (OC) SRC, (OR) nrcrc, OC (NRG) nrcrc, SC, RC (o)-SC(O)ORc, -SC(O)NRcRc, -SC(NRg)NRcRc, -N(Rg)C(O)Rc, -N[C(O)Rc]2, -N(ORg)C(O)Rc, -N(Rg)C(NRg)Rc, -N(Rg)N(Rg)C(O)Rc, -N[C(O)Rc]NRcRc, -N(Rg)C(S)Rc, -N(Rg)S(O)Rc, -N(Rg)S(O)ORc, -N(Rg)S(O)2Rc, -N[S(O)2Rc]2, -N(Rg)S(O)2ORc, -N(Rg)S(O)2NRcRc, -N(Rg)[S(O)2]2Rc, -N(Rg)C(
