It is related to identifying suitable subject with the method and composition of what treatment blood glucose illness and applies a effective amount of composition, the composition includes one or more opioid antagonists, anticonvulsive drug and psychotropic drugs. The composition may include insulin. In some embodiments, these method and compositions can be used to adjust blood glucose level. In preferred embodiments, these method and compositions what increases subject to the sensibility of insulin.用於治療血糖病症的方法和組合物涉及鑒定合適的受試者和施用有效量的組合物，所述組合物包括一種或多種阿片樣物質拮抗劑，抗驚厥藥和精神治療藥。所述組合物可包括胰島素。在一些實施方案中，可使用這些方法和組合物調節血糖水平。在優選實施方案中，這些方法和組合物用於增加受試者對胰島素的敏感性。
