Adeno-associated viral vectors for treating myocilin (MYOC) glaucoma

• 收藏
• 分享

专利权人:

Genzyme Corporation

发明人:

Pechan, Peter,Scaria, Abraham,Ardinger, Jeffery

申请号：

AU2015317756

公开号：

AU2015317756A1

申请日:

2015.09.16

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Provided herein are methods for treating myocilin (MYOC) glaucoma using adeno-associated viral (AAV) vectors. In some aspects, the AAV vectors encode R-spondin 1 (RSPO1), R-spondin 2 (RSPO2), R-spondin 3 (RSPO3) or R-spondin 4 (RSPO4) and/or RNAi that targets myocilin (MYOC). In one aspect, viral particles are administered to the eye of a human subject. Viral particles encoding RSPO1, RSPO2, RSPO3 and/or RSPO4 and/or MYOC RNAi are contemplated. In some aspects, variant AAV2 particles that transduce the trabecular meshwork are provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/