LUNDY, DAVID,伦迪 大卫,倫迪 大衛,HSIEH, PATRICK CH,谢清河,謝清河,伦迪 大卫,倫迪 大衛
申请号：
TW104126958
公开号：
TWI559928B
申请日:
2015.08.19
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (BBB) of a subject. The method includes administering to the subject in sequence or concomitantly, an effective amount of a growth factor selected from the group consisting of, vascular endothelial growth factor (VEGF), insulin-like growth factor I (IGF-1), IGF-II, a portion thereof and a combination thereof； and an agent that is any of a therapeutic agent or an imaging agent. The administered amount of the growth factor is capable of transiently increasing BBB permeability of the subject and thereby allowing the agent to be delivered across BBB. Also disclosed herein is a method of treating a subject suffering from a brain tumor, a brain stroke, a neuropsychiatric disorder and/or a neurodegenerative disease.在此揭示一種協助傳遞一製劑通過一個體之血腦障壁的方法。所述方法包含以接續或同時施用之方式，施用一有效量之生長因子以及一製劑，其中該生長因子係選自於血管內皮生長因子、第一型類胰島素生長因子、第二型類胰島素生長因子、其之一部分或組合所組成之群組，該製劑可以是任一種治療劑或造影劑。所述生長因子的施用量是能夠暫時性地增加個體之血腦障壁通透性，使得製劑可被傳遞通過血腦障壁。在此也同時揭示一種治療罹患腦腫瘤、腦梗塞、神經精神疾病和/或神經退化性疾病之個體的方法。
