SCHRØDER GLAD, Sanne Ormholt,BIRKEBÆK JENSEN, Kim,GRØN NØRAGER, Niels Henrik,SARVARY, Ian David,VESTERGAARD, Mikkel,HAAHR GOULIAEV, Alex,TEUBER, Lene,STASI, Luigi Piero
申请号：
PE2017000167
公开号：
PE20170682A1
申请日:
2015.07.31
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a substituted non cyclopentadiene derivative condensed from formula (I) or its salts, hydrates, solutions, polymorphs and stereoisomers, where y is NR u； R is h or C1-C4 optional substitution； R1 is H -, among others； R2 is h, halogen, etc.； R3 is hidogeno, halide, Among others, R4A is h, halide, etc.； r4b is h, halide, oxo, etc.； R5 is (cr8r9) po12, etc.； m, N and P are 0-4 integrity； r6a and R6b are h, halogen, C1-C6 alternative asphalt, etc.； R8, R9 and R12 are h, C1-C6 alternative asphalt, etc.； B is arilo type ring system, HeterosexualsC is, among other things, a C2-C9 isomerized ring system in which B combines with carbon atoms near the n of the C ring system, with the exception of compound (I). The most popular compounds are: (2R) - 4, 4-dimethyl-2 - [[6 - [2 - [4 - (trifluoromethyl) phenyl] pyridine-4-il] pyridine-4-il] pentachlorobenzene； (2R) - 2 - [[5-fluoro-2 - (trifluoromethyl) - 6 - [2 - [4-trifluoromethyl] phenyl] pyridine-1-il] pyridine-4-il] - amine] - 4, 4-diphenyl ether.There are others These compounds regulate the activity of the hole receptor associated with the retinoic acid receptor (ROR). You also mean a composer This compound is useful in the treatment of inflammatory, metabolic and autoimmune diseases.Se refiere a un derivado de pirimidina sustituido con heterociclilo opcionalmente condensado de formula (I) o las sales, hidratos, solvatos, polimorfos y estereoisomeros de los mismos, donde: Y es NR u O； R es H o alquilo C1-C4 opcionalmente sustituido； R1 es H, -OH, entre otros； R2 es H, halogeno, entre otros； R3 es hidogeno, halogeno, entre otros； R4a es H, halogeno, entre otros； R4b es H, halogeno, oxo, entre otros； R5 es (CR8R9)pOR12, entre otros； m, n y p son enteros de 0 a 4； R6a y R6b son H, halogeno, alquilo C1-C6 opcionalmente sustituido, entre otros； R8, R9 y R12 son H, alquilo C1-C6 opcionalmente sustituido, entre otros； B es un sistema de anillo tal como arilo, heteroarilo, entre otros； C es un sistema de anillo entre
