Philip Man Lung YEUNG,Fuk Woo Jasper CHAN,Manson FOK,Johnson Yiu-Nam LAU,Kwok-Yung YUEN
申请号：
US16333114
公开号：
US20190358326A1
申请日:
2017.09.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Enteroviruses, such as EV-A71, have been found to utilize hWARS as a cell surface receptor, with expression ofhWARS rendering cells susceptible to enteroviral infection. Reduction in hWARS cell surface activity reduces susceptibility to enteroviral infection and provides a mode for treatment or prevention of enteroviral infection and its sequelae. Similarly, expression of hWARS in cultured cells and animal models provides models for understanding enteroviral disease mechanisms and the development of vaccines and/or pharmaceuticals for preventing or treating enteroviral disease.
