Joseph SCHARITER,Kimberly HASSETT,Mike SMITH,Orn ALMARSSON,Luis BRITO
申请号：
US16643037
公开号：
US20200306191A1
申请日:
2018.08.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.
