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ИММУНОГЕННАЯ КОМПОЗИЦИЯ
专利权人:
СЕРУМ ИНСТИТЬЮТ ОФ ИНДИЯ ЛТД. (IN)
发明人:
КАПРЕ Субхаш Винаяк (IN),ПИСАЛ Самбхаджи Шанкер (IN)
申请号:
RU2014134288
公开号:
RU2014134288A
申请日:
2013.01.29
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An immunogenic composition, comprising polysaccharide conjugate N.meningitidis serogroup X - protein, wherein said capsular saccharide of serogroup X is derived from a strain of N.meningitidis serogroup X, selected from 8210 and 9601.2. The immunogenic composition of para. 1, characterized in that at least one additional saccharide conjugate (s) comprises capsular saccharide N.meningitidis, derived from serogroups A, C, W135 and Y.3. The immunogenic composition of para. 1, characterized in that the strain of N.meningitidis serogroup X is selected from 8210, 9601, 9592, 9554, and 2526.4. The immunogenic composition of para. 2, characterized in that the composition comprises capsular polysaccharides each of N.meningitidis serogroups A, C, W-135, Y & X by using at least two different carrier proteins for conjugation of 5 polisaharidov.5. The immunogenic composition of para. 4, characterized in that each N.meningitidis saccharide conjugated to a carrier protein selected from the group consisting of TT, DT, CRM197, fragment C of tetanus toxoid, protein D, OMPC and pnevmolizina.6. The immunogenic composition of para. 5, characterized in that each N.meningitidis saccharide conjugated to a carrier protein selected from the group consisting of TT, DT and CRM197.7. The immunogenic composition of claim. 6, characterized in that each N.meningitidis saccharide conjugated to a carrier protein selected from the group consisting of TT and DT.8. An immunogenic composition according to claim 4, characterized in that the composition comprises: (a) a conjugate of (i) capsular saccharide of serogroup A N.meningitidis and (ii) a tetanus toxoid. (B) a conjugate of (i) capsular saccharide of serogroup C N meningitidis and (ii) a tetanus toxoid (C) a conjugate of (i) capsular saccharide of serogroup Y N.meningitidis and (ii) a diphtheria toxoid (D) a conjugate of (i) capsular saccharide of serogroup W135 N.meningitidis and (ii) a tetanus toxoid and (d) a conjugate of (i) capsular sacchar
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