BU, Xianzhang,ZHU, Cuige,YUE, Xin,ZUO, Yinglin,CHEN, Yu,WEN, Gesi
申请号：
EP15740755
公开号：
EP3118204A4
申请日:
2015.01.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.
