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Deoxinojirimycin analogues and their uses as glucosylceramidase inhibitors
专利权人:
GENZYME CORPORATION
发明人:
AERTS, Johannes
申请号:
ES04793685
公开号:
ES2594356T3
申请日:
2004.10.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Deoxinojirimycin analogue or a pharmaceutically acceptable salt thereof, having the structure having the general structure (I): ** Formula ** in which R1, R3, R4 and R5 each independently comprise H or (CH2) nCH3 or X; n is 0-9; a, b, c, d, e are chiral centers that have an R or S configuration; and said deoxinojirimycin analog comprising at least one entity X, represented by: ** Formula ** comprising a large hydrophobic moiety Y and a spacer Z, according to which the large hydrophobic moiety is linked by the spacer to the nitrogen atom or atom of related carbon and in which the spacer Z is represented by (CH2) or, [(CH2) pP (CH2) q], in which 0>; = 0-9, p>; = 0-9, q>; = 0 -9, P>; = CH2 or CH2SCH2 or CH2OCH2 or ** Formula ** and the large hydrophobic Y moiety is selected from: ** Formula ** and said deoxinojirimycin analogue selected from the group consisting of: piperidines in which R2 >; = (CH2) nCH3 or X, R6>; = CH2OH or CH2OX ya>; = S, b>; = S, c>; = R, d>; = R, e>; = S beta-L-idopyranoside imitation, a>; = R , b>; = S, c>; = R, d>; = R, e>; = S alpha-L-idopyranoside imitation, piperidines in which R2>; = H, R6>; = CH2OH or CH2OX and b>; = S, c>; = R, d>; = R, e>; = S L-1-deoxyidopyranoside imitation.Análogo de desoxinojirimicina o una sal farmacéuticamente aceptable del mismo, que tiene la estructura que tiene la estructura (I) general:**Fórmula** en la que R1, R3, R4 y R5 comprenden cada uno independientemente H o (CH2)nCH3 o X; n es 0-9; a, b, c, d, e son centros quirales que tienen una configuración R o S; y comprendiendo dicho análogo de desoxinojirimicina al menos una entidad X, representada por:**Fórmula** que comprende un resto hidrófobo grande Y y un espaciador Z, según lo cual el resto hidrófobo grande está ligado por el espaciador al átomo de nitrógeno o átomo de carbono relacionado y en el que el espaciador Z está representado por (CH2)o, [(CH2)pP(CH2)q], en la que 0 >;= 0-9, p >;= 0-9, q >;= 0-9, P &
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