Bone implantable devices and methodologies permit careful application ofbiologically active substances and management of bone growth processes. Thedevice includes a body (300) defining a carrier receiving area for locatingadjacent bone. Carrier material (310) is located in the carrier receivingarea. Substance is delivered onto carrier material through a port (308). Apathway (370) delivers substance from the carrier receiving area to the bonesurface. The body may be in the form of a spinal fusion cage, facet fusionscrew, artificial joint, bone fixation plate, interbody graft, IM nail, hipstem, or other bone-to-bone appliances or bone-to-device appliances. In use,carrier is installed in the carrier receiving area of the device. The deviceis then implanted adjacent a bone. The substance is applied to the carrier forsubsequent delivery to the bone. By doping carrier material after deviceimplantation, inadvertent contact of the substance with non-target bone ismore easily eliminated.
