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NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS
专利权人:
发明人:
申请号:
EP09707528.7
公开号:
EP2234624B1
申请日:
2009.01.12
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.
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