ROBERTS, BRUCE L.,SHANKARA, SRINIVAS,BRONDYK, WILLIAM HAROLD,SIDERS, WILLIAM M.
申请号：
CA2761800
公开号：
CA2761800C
申请日:
2010.05.13
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to humanized immunoglobulins, mouse monoclonalantibodies and chimeric antibodiesthat have binding specificity for human CD52. The present invention furtherrelates to a humanized immunoglobulin lightchain and a humanized immunoglobulin heavy chain. The invention also relatesto isolated nucleic acids, recombinant vectors andhost cells that comprise a sequence which encodes a humanized immunoglobulinor immunoglobulin light chain or heavy chain,and to a method of preparing a humanized immunoglobulin. The humanizedimmunoglobulins can be used in therapeutic applicationsto treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma,multiple sclerosis and chronic lymphocyticleukemia.
