The negative gauge pressure moisture management and secure adherence artificial limb system is to be attached to a residual limb of an amputee. The artificial limb system includes a negative gauge pressure airflow liner, a surface area multiplying textile layer with a proximal airflow seal to surround at least a portion of the residual limb and define a regulated negative gauge pressure environment between the residual limb and the negative gauge pressure liner. The liner has a plurality of airflow passageways defining inflow air channels and an outflow air channel in fluid communication with the defined regulated negative gauge pressure environment. An airflow control system is connected inline with the outflow and inflow air channels. The airflow control system includes an airflow regulation device and an airflow initiating device.
