BAXTER, ANDREW,JOHNSON, TIMOTHY,KINDON, NICHOLAS,ROBERTS, BRYAN,STOCKS, MICHAEL
申请号：
ES03700655
公开号：
ES2375107T3
申请日:
2003.01.14
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein: R 1, R 2 and R 3 are independently hydrogen, halogen, cyano, CF3, OCF3, O-C1-6 alkyl or C1 alkyl -6； R 4 is halogen, CO2R 12, (I) C1-6 alkoxy in which the alkyl group may form a 3-6 membered saturated ring or may be substituted with 1-3 fluorine atoms or a cyano group； C3-6 alkenyloxy or C3-6 alkynyloxy in which anyone can optionally be substituted with hydroxy or NR 14 R 15； O-C 1-6 alkyl-X-C 1-6 alkyl in which the alkyl groups can form a saturated 3-6 membered ring； O-C1-6-R 11 alkyl or O-C2-6-XR 11 alkyl in which the alkyl group can form a 3-6 membered saturated ring and is optionally substituted with 1-3 groups selected from hydroxy, halogen, NR 14 R 15, SR 13, S (O) 2R 13, S (O) R 13 or COR 13； O-C1-6R 16 alkyl； R 5 and R 6 are independently hydrogen, cyano, halogen, CO2R 12, CONR 14 R 15； C1-6 alkyl optionally substituted by hydroxy, NR 14 R 15 or 1-3 fluorine atoms； C 1-6 alkyl 11 or XCH (R 11) C 1-6 alkyl or XCH (R 16) C 1-6 alkyl in which the alkyl group may optionally be substituted with 1-3 groups selected from hydroxy and NR 14 R 15； NR 14 R 15； N (R 11) R 11； X- (CH2) qNR 14 R 15； (CH2) nNR 14 R 15； NHC (O) C1-6 alkyl optionally substituted by one or more hydroxy, C3-6 alkynyl or C3-6 alkenyl optionally branched and optionally substituted with 1-3 groups selected from hydroxy, cyano, halogen y = O； R 11； X-R 11； X-R 12； X-C1-6R alkyl 16； X-R 16； X- (CH2) nCO2R 12； X- (CH2) nCONR 14 R 15； X- (CH2) nR 11； X- (CH2) nCN； X- (CH2) qOR 12； (CH2) No. 12； (CH2) n-X-R 11； X- (CH2) qNHC (O) NHR 12； X- (CH2) qNHC (O) R 12； X- (CH2) qNHS (O) 2R 12； X- (CH2) qNHS (O) 2R 11； X-C3-6 alkenyl； X-C3-6 alkynyl； n is 1, 2, 3, 4 or 5； q is 2, 3, 4, 5 or 6； X is NR 13, O, S, S (O), S (O) 2； R 11 is an aryl group or a 5-7 membered heteroaromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulfur, each of which may be optionally substituted by 1-3 groups selected
