System of the present invention discloses a kind of novel biological flag object: miR-134, miR-223, IL-18, had by the what biomarker system and adult onset's history flute Er Shi disease and its mobility and is positively correlated, therefore, by the performance amount in the biological flag object what sample of detection at least one, be can reach detection sample supplier fall ill risk and pre- Hou the effect of.本發明係揭露一種新穎生物標幟物:miR-134、miR-223、IL-18,由於該生物標誌物係與成人發作型史笛兒氏症及其活動度具有正相關,因此,藉由檢測至少一生物標幟物於樣本中之表現量,係能夠達到檢測樣本提供者之罹病風險及預後之功效。