STOCK, Nicholas Simon,CHEN, Austin Chih-yu,BRAVO, Yalda Mostofi,JACINTHO, Jason Duarte,BACCEI, Jill Melissa,STEARNS, Brian Andrew,CLARK, Ryan Christopher
申请号：
ES13863783
公开号：
ES2660249T3
申请日:
2013.12.10
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I ** Formula ** or a pharmaceutically acceptable salt thereof where: A1 is a phenyl ring or a 6-membered heteroaromatic ring having 1, 2 or 3 N in the heteroaromatic ring； A2 is selected from A2a or A2b ** Formula ** where A2a is a phenyl ring or a 6-membered heteroaromatic ring that has 1, 2 or 3 N in the heteroaromatic ring, and A2b is a 5-membered heteroaromatic ring that has 1 , 2 or 3 heteroatoms independently selected from O, S and N； X is selected from the group consisting of - (CH2) 2-, - (CH2) 3-, - (CH2) 4-, and - (CH2) mO- (CH2) n-, mono- or optionally disubstituted with halogen, where m and n are independently 0, 1, 2, 3 or 4, provided that m + n is 2, 3 or 4； Cast； R1 and R2 are each independently selected from the group consisting of: (a) hydrogen, (b) halogen, (c) CN, (d) CF3, (e) -C1-6 alkyl, (f) - (C1-6 alkyl) -C (>； = O) OH, (g) -O- (R7), (h) -S (>； = O) or R7, (i) -N (R7) (R8), ( j) -N (R7) -C (>； = O) - (R8), (k) -N (R7) -C (>； = O) -O- (R8), (l) -N (R7) S (>； = O) 2 (R8), (m) - (C3-6 cycloalkyl), (n) -C (>； = O) (R7), (o) aryl, (p) heteroaryl, (q) -OC (>； = O) N (R7) (R8), (r) -S (>； = O) 2N (R7) (R8), (s) -C (>； = O) N (R7) (R8) and ( t) -C (R7) (R8) OH, where the alkyl portion of options (e) and (f), and the cycloalkyl portion of option (m) are optionally substituted with halogen, and where the aryl of option (o) and the heteroaryl of option (p) are mono- or optionally substituted with substituents selected from halogen, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C3-6 cycloalkyl, C3-6 cycloalkoxy, -NH (C1-6 alkyl), -NH (C3-6 cycloalkyl), -N (C1-6 alkyl) 2, -N (C3-6 cycloalkyl) 2, -S (>； = O) or (C1-6 alkyl), - S (>； = O) or (cycloalq C3-6 uyl) and CN； R3 is selected from the group consisting of: (a) hydrogen, (b) halogen, (c) CN, (d) CF3, (e) -C1-6 alkyl, (f) - (C1-6 alkyl) - C (>； = O) OH, (g) -O- (R7), (h) -S (>； = O) or R7 (i) -N (R7) (R8), (j) -N (R7) - C (>； = O) - (R8), (k) -N (R7) -
