THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;VANDERBILT UNIVERSITY
发明人:
POZZI, AMBRA A.,CHIUSA, MANUEL,HAWIGER, JACK J.,ZIENKIEWICZ, JOZEF
申请号：
CA3051855
公开号：
CA3051855A1
申请日:
2018.01.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases.
