Provided are silica-based biomolecular carriers for delivering biomolecules to cells, compositions comprising the same, methods of making the same and uses thereof. The silica-based biomolecular carrier comprises a porous core, a first physiologically active part, a second physiologically active part functionally related to the first physiologically active part, a first physiologically active part and a second And linkers which respectively conjugate the physiologically active moiety to the porous core. [Selected figure] Figure 5A.生体分子を細胞へと送達するためのシリカ系生体分子担体、それを含む組成物、並びにその製造方法及びその使用が提供される。シリカ系生体分子担体は、多孔質コアと、第１の生理活性部分と、第１の生理活性部分と機能的に関連する第２の生理活性部分と、第１の生理活性部分及び第２の生理活性部分を多孔質コアにそれぞれ複合化するリンカーとを含む。【選択図】図５Ａ
