Sudhir Paul,Yasuhiro Nishiyama,Stephanie Planoue,Richard J. Massey
申请号：
US13184530
公开号：
US20120121633A1
申请日:
2011.07.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are immunogenic compositions based on the highly conserved, core CD4 binding site of the gp120 protein of the human immunodeficiency virus. One embodiment includes an antigenic conjugate of an electophilic derivative of HIV gp120 peptide 416-433, designated E-416-433, covalently linked to an immunogenic carrier protein. The compositions are effective in stimulating the production of HIV neutralizing antibodies in mammals. Provided also are related methods of immunization, methods of antibody production and antibodies obtained using the methods of the invention.
