Rudolf Valenta,Susanne Vrtala,Sabine Stumvoll,Hans Grönlund,Monika Grote,Luca Vangelista,Annalisa Pastore,Wolfgang R. Sperr,Peter Valent,Dietrich Kraft
申请号：
US11933498
公开号：
US08440200B2
申请日:
2007.11.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods for desensitization of a mammal suffering from IgE mediated allergy comprise the steps of: administering to said mammal a therapeutically effective amount of an immunogenic and hypoallergenic composition which comprises (i) a Phl p 6 molecule having an N-terminal truncation which makes the molecule at least lack IgE binding capacity, and/or (ii) a Phl p 6 molecule having a C-terminal truncation which makes the molecule at least lack IgE binding capacity, wherein the molecules of (i) and (ii), if employed in combination, together span the complete sequence of Phl p 6, and a pharmaceutically acceptable carrier.
