STEALTH PEPTIDES INTERNATIONAL, INC.;HENRY FORD HEALTH SYSTEMS
发明人:
WILSON, D. TRAVIS,SABBAH, HANI N.
申请号：
CA2889155
公开号：
CA2889155A1
申请日:
2013.10.22
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The disclosure provides methods of preventing or treating heart failure in a mammalian subject, reducing risk factors associated with heart failure, and/or reducing the likelihood or severity of heart failure. The disclosure also provides methods of preventing, or treating LV remodeling in a mammalian subject, and/or reducing the likelihood or severity of LV remodeling. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide. In some embodiments, the methods comprise administering to the subject an effective amount of an aromatic cationic peptide to reduce levels of C-reactive protein, tumor necrosis factor alpha, interleukin 6, reactive oxygen species, Nt-pro BNP, and/or cardiac troponin I, and/or reduce expression levels of MLCL AT1 and/or ALCAT 1 in subjects in need thereof.
