CONJUGATION OF LIPOPHILIC ALBUMIN-BINDING MOIETY TO RNA FOR IMPROVED CARRIER-FREE IN VIVO PHARMACOKINETICS AND GENE SILENCING

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专利权人:

发明人:

Craig L. Duvall,Samantha M. Sarett,Thomas A. Werfel

申请号：

US15671131

公开号：

US20180064749A1

申请日:

2017.08.07

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.

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