JUNG, SUNG YOUB,郑圣烨,鄭聖燁,HWANG, SANG YOUN,黄祥渊,黃祥淵,KIM, SEUNG SU,金承洙,CHOI, IN YOUNG,崔仁荣,崔仁榮,KWON, SE CHANG,权世昌,權世昌
申请号：
TW104117391
公开号：
TW201625292A
申请日:
2015.05.29
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to a composition for preventing or treating diabetes mellitus comprising insulin and a GLP-1/glucagon dual agonist, and a method for preventing or treating diabetes mellitus. More specifically, the present composition can inhibit the weight gain and reduce the danger of hypoglycemia due to the administration of insulin, lower the administration dose and greatly improve the compliance of drugs through a combined administration of a long-acting insulin conjugate and a long-acting GLP-1/glucagon dual agonist conjugate. In addition, the long-acting insulin conjugate and the long-acting GLP-1/glucagon dual agonist conjugate according to the present invention can improve the in vivo sustainability and stability because an insulin and a GLP-1/glucagon dual agonist are linked to the immunoglobulin Fc region via a non-peptidyl linker.本發明係有關一種預防或治療糖尿病之組成物，其包含胰島素與GLP-1/昇糖素雙重促效劑，並有關一種預防或治療糖尿病之方法。更明確言之，本發明組成物可以透過組合投與長效性胰島素接合物與長效性GLP-1/昇糖素雙重促效劑接合物來抑制因胰島素投藥所引起之體重上升及降低低血糖風險，並減少投藥量，大幅改善藥物適應性。此外，根據本發明之長效性胰島素接合物與長效性GLP-1/昇糖素雙重促效劑接合物中，由於胰島素與GLP-1/昇糖素雙重促效劑係利用非肽基連接體連接免疫球蛋白Fc區，因此可以改善活體內之持續效力及安定性。
