A kind of wisdom phototherapy sterilization bed, includes a mattress, a sterili-sation unit, a phototherapy unit, a pressure sensing cells and a manipulation unit. The pressure sensing cells can detect the compression situation of the mattress, and export a detection signal. The manipulation unit can be according to the detection signal, whether detecting, which has user to lie, is slept on the what mattress, when no user lies and sleeps, is driven the sterili-sation unit enable and is issued ultraviolet light to the mattress, to carry out sterilization process to the mattress, to reduce the chance of infection germ and anaphylactia； When thering is user to lie to sleep, drives the phototherapy unit enable and low-energy light is issued to user, to promote the sleep quality and blood circulation of user.一種智慧光療殺菌床，包含一個床墊、一個殺菌單元、一個光療單元、一個壓力感測單元，及一個操控單元。該壓力感測單元可偵測該床墊的受壓情況，而輸出一個偵測訊號。該操控單元可根據該偵測訊號，偵測是否有使用者躺睡於該床墊上，在無使用者躺睡時，驅動該殺菌單元致能而對該床墊發出紫外光，以對該床墊進行殺菌作業，來減少感染病菌與過敏性疾病的機會；在有使用者躺睡時，驅動該光療單元致能而對使用者發出低能量光，以增進使用者的睡眠品質與血液循環。
