LEUNG KINMEI,SUN HAIJUN,BATEY SARAH,ROWLAND ROBERT
申请号：
IN201617011792
公开号：
IN201617011792A
申请日:
2016.04.04
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which will respond to treatment with a specific binding member comprising a HER2 antigen binding site engineered into a structural loop region of a constant domain e.g. CH3 domain of the specific binding member and specific binding members which compete with such a binding member for binding to HER2.
