Cassandra CELATKA,John M. MCCALL,Michael CLARE,Hugh Young RIENHOFF, JR.,Amy E. TAPPER
申请号：
MX2017010291
公开号：
MX2017010291A
申请日:
2016.02.12
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia. Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia. A method can include receiving data for a geologic environment where the data include data acquired via different types of borehole tool sensors； based at least in part on the data, determining rock composition of the geologic environment where the rock composition includes depositional components and diagenetic components； and, based at least in part on the rock composition, outputting a stratigraphic model of at least a portion of the geologic environment.En el presente documento se dan a conocer nuevos compuestos y composiciones, y su aplicación como productos farmacéuticos para el tratamiento de enfermedades. También se proporcionan métodos de inhibición de KDM1A, métodos para incrementar la expresión del gen de gamma globina y métodos para inducir la diferenciación de células cancerosas en un sujeto humano o animal, para el tratamiento de enfermedades tales como la leucemia mielógena aguda.
