A portable hyperbaric chamber with a vertical mounting system includes an inflatable enclosure which is vertically positioned by a rigid base. An internal frame also functions as an additional mounting system so that the inflatable enclosure can be vertically positioned during pressurized and not pressurized instances. A plurality of fill valves allows the inflatable enclosure to be pressurized from externally positioned compressors, and the inside pressure of the inflatable enclosure is measured and displayed through a pressure gauge. The inside pressure can be controlled from a dump valve, a low pressure relief valve, and a high pressure relief valve so that the proper operating pressure can be maintained with the hyperbaric chamber.