James Yoo;Mark Van Dyke;Sang Jin Lee;Anthony Atala
发明人:
James Yoo,Sang Jin Lee,Mark Van Dyke,Anthony Atala
申请号：
US12991811
公开号：
US09694055B2
申请日:
2009.05.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
