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ORGANOLEPTIC ACCEPTABLE ORAL DOSAGE FORM OF IBUPROFEN AND METHODS FOR ITS PREPARATION AND APPLICATION
专利权人:
ТЕЙКОКУ ФАРМА ЮЭсЭй; Инк. (US)
发明人:
ХИБИ Тору (US)
申请号:
RU2012138581/15
公开号:
RU2012138581A
申请日:
2012.09.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Organoleptically acceptable solid oral dosage form of ibuprofen, comprising: ibuprofen; taste-masking agent selected from malic acid, citric acid, glutamic acid and taurine; moreover, if cyclodextrin is present in the dosage form, the total amount is less than twice the amount of ibuprofen (by weight); moreover, the dosage form is intended for resorption or chewing. 2. The dosage form according to claim 1, characterized in that the taste masking agent further comprises a refreshing agent. The dosage form according to claim 2, characterized in that said refreshing agent is selected from the group consisting of L-menthol, DL-menthol, WS-23 (N, 2,3-trimethyl-2-isopropylbutamide), WS-3 ( N-ethyl-5-methyl-2- (1-methylethyl) cyclohexanecarboxamide), peppermint oil and curly peppermint oil. 4. Dosage form according to claim 1, characterized in that the taste masking agent further comprises cyclo dextrin. A dosage form according to claim 1, characterized in that said solid dosage unit form is a candy, lozenge, tablet, or chewing gum. Dosage form according to any one of claims 1 to 5, characterized in that ibuprofen is present in an amount of from about 50 mg to about 200 mg. A dosage form according to any one of claims 1 to 5, characterized in that it consists of a mixture of: ibuprofen; taste-masking agent; diluent; lubricating agent. 8. A dosage form according to any one of claims 1 to 5, characterized in that it consists of a mixture of: ibuprofen; two or more taste-masking agents; diluent; lubricating agent. 9. Drug1. Органолептически приемлемая твердая пероральная дозированная лекарственная форма ибупрофена, содержащая:ибупрофен; имаскирующее вкус средство, выбранное из яблочной кислоты, лимонной кислоты, глутаминовой кислоты и таурина;причем в случае присутствия в составе лекарственной формы циклодекстрина общее его количество составляет менее удвоенного количества ибупрофена (по массе);причем лекарственная форма предназначена для рассасывания или разжевывания.2. Л
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