A spinal construct includes a guide having a first member and a second member. The first member includes an inner surface defining a guide cavity. The second member extends in a transverse orientation relative to the first member. A first fastener includes a first end and a second end. The first end defines an implant cavity and a second end is configured for penetrating tissue. A second fastener is disposable in the guide cavity such that the inner surface aligns the second fastener for penetrating tissue. Systems and methods are disclosed.