ESPOSITO, LUKE A.,HUDSON, F. MICHAEL,LAKE, THOMAS,CUMMINGS, JOEL,SNOW, ALAN D.,WEIGELE, MANFRED,LARSEN, LESLEY
申请号：
PE0008352011
公开号：
PE09302011A1
申请日:
2009.06.26
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a phenyl derivative Compound of formula (i), wherein R1, R2, R3 and R4 are hydroxyl groups R is imidazole, pyrazole or triazole. Preferred compounds are: 2,4-bis (3,4-dihydroxyphenyl) imidazole (3,5-bis - (3,4-dihydroxyphenyl) - triazole, 3,5-bis (3,4-dihydroxyphenyl) pyrazole. It also relates to a Pharmaceutical composition.These compounds inhibit the formation, deposition or accumulation of beta Amyloid Protein Aggregates or Alpha sinucleinas and are useful in the treatment of Alzheimers disease, Parkinsons disease and synucleinopathiesREFERIDA A UN COMPUESTO DERIVADO DE FENILO DE FORMULA (I), DONDE R1, R2, R3 Y R4 SON GRUPOS HIDROXILOS R ES IMIDAZOL, TRIAZOL O PIRAZOL. SON COMPUESTOS PREFERIDOS: 2,4-BIS(3,4-DIHIDROXIFENIL)IMIDAZOL, 3,5-BIS(3,4-DIHIDROXIFENIL)-1,2,2-TRIAZOL, 3,5-BIS(3,4-DIHIDROXIFENIL)PIRAZOL. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA FORMACION, DEPOSITO O ACUMULACION DE PROTEINAS BETA-AMILOIDES O AGREGADOS ALFA-SINUCLEINAS Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, PARKINSON Y SINUCLEINOPATIAS
